publications

Peer-reviewed

1. BMC Biol.

   Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types

   Chiara M. L. Loeffler, Omar S. M. El Nahhas, Hannah S. Muti, Zunamys I. Carrero, Tobias Seibel, Marko Treeck, Didem Cifci, Marco Gustav, Kevin Bretz, Nadine T. Gaisa, Kjong-Van Lehmann, Alexandra Leary, Pier Selenica, Jorge S. Reis-Filho, Nadina Ortiz-Bruechle, and Jakob Nikolas Kather

   BMC Biology, Oct 2024

   Abs DOI Bib HTML PDF

   Homologous recombination deficiency (HRD) is a pan-cancer predictive biomarker for response to PARP inhibitors, but standard HRD testing is complex. This study develops a deep-learning pipeline using attention-based multiple instance learning (attMIL) to predict HRD status directly from routine H&E histology across nine tumor types, showing that a breast-cancer-trained classifier transfers to endometrial, prostate, and pancreatic cancer.

   @article{loeffler2024hrd,
     keywords = {reviewed},
     title = {Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types},
     author = {Loeffler, Chiara M. L. and El Nahhas, Omar S. M. and Muti, Hannah S. and Carrero, Zunamys I. and Seibel, Tobias and van Treeck, Marko and Cifci, Didem and Gustav, Marco and Bretz, Kevin and Gaisa, Nadine T. and Lehmann, Kjong-Van and Leary, Alexandra and Selenica, Pier and Reis-Filho, Jorge S. and Ortiz-Bruechle, Nadina and Kather, Jakob Nikolas},
     journal = {BMC Biology},
     volume = {22},
     number = {225},
     year = {2024},
     month = oct,
     publisher = {Springer Nature},
     doi = {10.1186/s12915-024-02022-9},
   }

Preprints

1. arXiv

   Silent Metronome: Rhythmic Grounding for Live Music Accompaniment

   Kevin Bretz, Derya Soydaner, and Aske Plaat

   arXiv preprint , Sep 2026

   arXiv Bib Code Website

   @misc{bretz2026silentmetronome,
     keywords = {preprint},
     title = {Silent Metronome: Rhythmic Grounding for Live Music Accompaniment},
     author = {Bretz, Kevin and Soydaner, Derya and Plaat, Aske},
     year = {2026},
     month = sep,
     archiveprefix = {arXiv},
     primaryclass = {cs.SD},
   }

Conference papers and talks

1. MW:M

   Towards Intelligent Instruments: From One-Shot Tools to Collaborative Music AI - A Survey and Position

   Kevin Bretz, Derya Soydaner, and Aske Plaat

   In Most Wanted: Music Research (MW:MR), Nov 2026

   Accepted, to appear

   Bib PDF

   @inproceedings{bretz2026intelligentinstruments,
     keywords = {conference},
     title = {Towards Intelligent Instruments: From One-Shot Tools to Collaborative Music AI - A Survey and Position},
     author = {Bretz, Kevin and Soydaner, Derya and Plaat, Aske},
     booktitle = {Most Wanted: Music Research (MW:MR)},
     address = {Berlin, Germany},
     year = {2026},
     month = nov,
     note = {Accepted, to appear},
   }